Table 4. Mean values for effects of the drugs on biochemical parameters.
| Groups | Biochemical parameters | |||||
|---|---|---|---|---|---|---|
| IL-1 beta | IL-6 | TNF alpha | ||||
| Plasma (pg/mL) | Brain (pg/mg wet tissue) | Plasma (pg/mL) | Brain (pg/mg wet tissue) | Plasma (pg/mL) | Brain (pg/mg wet tissue) | |
| Control | 55.5±3.3 | 51.3±1.2 | 215.2±7.0 | 385.7±83.7 | 306.4±24.3 | 179.6±12.0 |
| NS+PTZ | 215.8±8.2 | 275.2±4.3 | 503.2±33.2 | 963.1±68.2 | 423.9±47.7 | 203.6±5.0 |
| 5-HT+PTZ | 74.2±2.0 | 86.3±8.5 | 217.7±2.3 | 402.3±40.3 | 317.7±49.3 | 187.9±10.2 |
| Fluoxt+PTZ | 72.3±4.7 | 84.0±5.2 | 207.3±10.2 | 387.8±17.5 | 315.5±24.6 | 180.9±7.1 |
| Sumt+PTZ | 130.2±12.6 | 147.4±6.6 | 256.4±21.0 | 922.3±61.0 | 349.6±5.3 | 191.4±11.8 |
Values are presented as mean ± SEM. SEM: standard error of the mean; IL: interleukin; NS: normal saline; 5-HT: serotonin; fluoxt: fluoxetine; sumt: sumatriptan; PTZ: pentylenetetrazole; GTCS: generalized tonic-clonic seizures.