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Schematic diagram showing the mechanism underlying ChRCC sensitivity to ferroptosis. (A) ChRCC cells enhance cystine uptake and GCLC expression to synthesize glutathione (GSH). GPX4 utilizes GSH to neutralize lipid ROS and prevent ferroptosis. (B) Cystine deprivation by cyst(e)inase, erastin, or IKE suppresses GSH synthesis, leading to accumulation of lipid ROS and ferroptotic cell death. Dashed arrows indicate defective pathways. Glu, glutamate; Cys-gly, cysteinylglycine.
