Table 4.

Economic analysis: incremental effect and cost and ICER estimation from bootstrapping

Utility computation	Incremental effect	Incremental cost in €	ICER in €/QALY
	Mean difference (95%CI)	Mean difference (95%CI)	Estimate ICER (95%CI)
EQ-5D-5L index	0.0039 (− 0.0927, 0.0931)	118.72* (110.75, 128.27)	30,421.70 (21,737.41–50,744.77)
Near VA value	0.1001 (0.0679, 0.1346)		1186.20 (1181.12–1191.34)

CI confidence interval, ICER incremental cost-effectiveness ratio, VA visual acuity, QALY quality-adjusted life years

*This value for incremental costs is the result of bootstrapping and because of that can be different from the obtained during the trial and given in the text