Table 1.
Antibody responses to VLP-S2 and VLP-S2mutS2’ after prime and boost in Syrian hamsters.
| Spike IgG Endpoint Titer |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SARS-CoV-2 |
||||||||||||||
| 614D |
B.1.351 |
SARS-CoV-1 |
HKU-1 |
OC43 |
NL63 |
229E |
||||||||
| Vaccine group | Geometric mean | Geometric SD factor | Geometric Mean | Geometric SD factor | Geometric mean | Geometric SD factor | Geometric mean | Geometric SD factor | Geometric mean | Geometric SD factor | Geometric mean | Geometric SD factor | Geometric mean | Geometric SD factor |
| MS2-SA VLP | <20 | – | <20 | – | <20 | – | <20 | – | <20 | – | <20 | – | <20 | – |
| VLP-S2 | 292,667 | 1.98 | 206,425 | 1.49 | 25,803 | 2.23 | 12,902 | 1.49 | 32,404 | 2.23 | 10,240 | 2.00 | 8127 | 1.49 |
| VLP-S2mutS2' | 291,930 | 1.33 | 206,425 | 1.49 | 40,960 | 2.00 | 12,902 | 1.49 | 32,510 | 2.23 | 10,240 | 2.00 | 5120 | 2.00 |
Viral antibody endpoint titers against the SARS-CoV-2 spike (three animals in each group). Endpoint titers using 2-fold diluted sera were expressed as the reciprocal of the highest dilution with an optical density at 490 nm cutoff value > 0.15; sera were collected on day 42 after the initial immunization.