Table I.

Overview of pictorial blood-loss assessment chart and menstrual pictogram data for assessing menstrual blood loss in clinical trials.^a

	PBAC	MP
Sensitivity and specificity	Diagnosis of MBL >80 ml (n = 950) (Higham et al., 1990; Deeny and Davis, 1994; Janssen et al., 1995; Barr et al., 1999; Reid et al., 2000; Zakherah et al., 2011; Hald and Lieng, 2014): Sensitivity: 58–99% Specificity: 7.5–89% Diagnosis of self-perceived HMB Sensitivity: 78.5% Specificity: 75.8% (n = 429) (Hald and Lieng, 2014)	Diagnosis of MBL >80 ml (Wyatt et al., 2001; Magnay et al., 2014) or identifying ≥50% decrease in MBL (n = 314) (Larsen et al., 2013): Sensitivity: 82–96% Specificity: 88–94%
Predictive value	Predictive value of diagnosing HMB with a PBAC score cut-off of 100 (n = 103) (Reid et al., 2000): PPV: 62% NPV: 60% Predictive value of diagnosing HMB with a modified PBAC score cut-off of 185 (n = 288) (Janssen et al., 1995): PPV: 85.9% NPV: 84.8% Predictive value of diagnosing HMB with a complaint of heavy MBL (n = 288) (Janssen et al., 1995): PPV: 55.9%	Predictive value of diagnosing HMB (n = 170) (Larsen et al., 2013): PPV: 91% NPV: 83%
Correlation with MBL assessed by AH method	Moderate-to-high (r = 0.466–0.847) correlation with MBL or change in MBL from baseline assessed by the AH method (n = 328) (Higham et al., 1990; Reid et al., 2000; Zakherah et al., 2011)	High (r = 0.81–0.86) correlation with MBL or change in MBL from baseline (n = 206) (Larsen et al., 2013; Magnay et al., 2014)

PBAC

Sensitivity and specificity

Diagnosis of MBL >80 ml (n = 950) (Higham et al., 1990; Deeny and Davis, 1994; Janssen et al., 1995; Barr et al., 1999; Reid et al., 2000; Zakherah et al., 2011; Hald and Lieng, 2014):

Sensitivity: 58–99%
Specificity: 7.5–89%

Diagnosis of self-perceived HMB

Sensitivity: 78.5%
Specificity: 75.8% (n = 429) (Hald and Lieng, 2014)

Diagnosis of MBL >80 ml (Wyatt et al., 2001; Magnay et al., 2014) or identifying ≥50% decrease in MBL (n = 314) (Larsen et al., 2013):

Sensitivity: 82–96%
Specificity: 88–94%

Predictive value

Predictive value of diagnosing HMB with a PBAC score cut-off of 100 (n = 103) (Reid et al., 2000):

PPV: 62%
NPV: 60%

Predictive value of diagnosing HMB with a modified PBAC score cut-off of 185 (n = 288) (Janssen et al., 1995):

PPV: 85.9%
NPV: 84.8%

Predictive value of diagnosing HMB with a complaint of heavy MBL (n = 288) (Janssen et al., 1995):

PPV: 55.9%

Predictive value of diagnosing HMB (n = 170) (Larsen et al., 2013):

PPV: 91%
NPV: 83%

Correlation with MBL assessed by AH method

Moderate-to-high (r = 0.466–0.847) correlation with MBL or change in MBL from baseline assessed by the AH method (n = 328) (Higham et al., 1990; Reid et al., 2000; Zakherah et al., 2011)

High (r = 0.81–0.86) correlation with MBL or change in MBL from baseline (n = 206) (Larsen et al., 2013; Magnay et al., 2014)

Data shown are for different versions of the MP and PBAC, which may have been adapted for use for study purposes. A full review of these data has been published (Magnay et al., 2018).

PBAC, pictorial blood-loss assessment chart; MP, menstrual pictogram; MBL, menstrual blood loss; HMB, heavy menstrual bleeding; AH, alkaline hematin; PPV, positive predictive value; NPV, negative predictive value.