Table 2.

Recommended NAC dosing as part of the therapeutic strategy for COVID-19.

Clinical scenario	Dose (route of administration)	Reference
Infection prophylaxis Outpatient treatment Mild disease	600 mg BID (oral)	De Flora et al., 2020[23] Shi & Puyo, 2020[17]
Inpatient treatment Mild to moderate disease	600 mg TID (oral)	Izquierdo et al., 2022[49]
Inpatient treatment IRCU Moderate to severe disease	300 mg TID (IV)	Frades et al., 2020[46]
Inpatient treatment ICU Severe disease	300 mg 5–6 ID (IV)	Gaynitdinova et al., 2021 Shi[44]

BID, twice a day; ICU, intensive care unit; IRCU, intermediate respiratory care unit, IV, intra-venous; TID, three times a day.