TABLE 1.
Virulence of wild-type and PLO-1 strains of A. pyogenes
| Challenge strain and CFU | No. infected/total no. | Avg bacterial viable count (CFU) from infected mouse specimen:
|
||
|---|---|---|---|---|
| Blooda | Liver | PF | ||
| BBR1 | ||||
| 3.7 × 107 | 0/8 | —b | — | — |
| 3.7 × 108 | 7/8 | 3.9 × 103 | 1.9 × 108 | 8.7 × 107 |
| 3.7 × 109 | 8/8 | NDc | ND | ND |
| PLO-1 | ||||
| 4.1 × 108 | 0/8 | — | — | — |
| 4.1 × 109 | 3/8 | 1.0 × 103 | 9.0 × 105 | 3.4 × 106 |
| 4.1 × 1010 | 8/8 | 4.0 × 105 | 5.7 × 108 | 6.6 × 109 |
| PLO-1(pEP2) | ||||
| 2.4 × 108 | 0/3 | — | — | — |
| PLO-1(pJGS75) | ||||
| 2.8 × 108 | 3/3 | 3.5 × 102 | 1.5 × 107 | 1.1 × 107 |
a
Minima detected are 100 CFU/ml of blood, 500 CFU/g of liver, and 10 CFU/ml of PF.
b
—, below the limits of detection.
c
ND, not determined.