FIG. 7.

Cytokine production by CD4⁺ Th cells from BL/6 and CBA mice stimulated with the 62-kDa antigen. CD4⁺ Th cells were isolated from mesenteric lymph nodes of 8.5-week-infected mice. Culture conditions were as described in Materials and Methods. The cytokines IFN-γ, IL-2, IL-4, and IL-5 were measured in culture supernatants by ELISA. Data are expressed as mean ± 1 SD. Also shown for comparison are responses to Sm-p40 and SEA. The same pattern of cytokine production was observed when cells from 8-week-infected mice were used (not shown).