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. 2022 Jun 16;31(22):3789–3806. doi: 10.1093/hmg/ddac132

Figure 4.

Figure 4

Regional plots of novel association signals found from the meta-analysis between the SCOURGE and CNIO studies. Regional plots of novel association signals found in 9p13.3 (A–C), 17q21.31 (D–F) and 19q13.12 (G–I). The x axes reflect the chromosomal position, and the y axes the −log(P-value) of the SCOURGE-CNIO meta-analysis. On A, D and G the sentinel variant is indicated by a diamond and all other variants are color coded by their degree of LD with the sentinel variant in Europeans. Whenever a concise set of variants was prioritized, a credible set is shown within a dashed square. The horizontal dotted blue line corresponds to the threshold for genome-wide significance (P = 5 × 10−8). In the rest of panels, the x axes reflect the chromosomal position, and the y axes the −log(P-value) resulting from the eQTL analyses in whole blood (B, E and H) and in the lung (C, F and I) whenever a significant finding is available from GTEx v8.