Table 3.

Genome-wide significant variants in global or sex-stratified meta-analysis between the SCOURGE and CNIO studies

SNP	chr:position			Meta-ALL			Meta-males			Meta-females			Nearest gene
		EA	NEA	beta	SE	P-value	beta	SE	P-value	beta	SE	P-value
rs115679256	3:45587795	G	A	0.43	0.08	1.1E−08	0.48	0.10	2.3E−06	0.40	0.11	2.9E−04	LIMD1
rs17763742	3:45805277	A	G	0.60	0.05	4.1E−29	0.74	0.07	3.3E−25	0.43	0.08	4.5E−08	LZTFL1
rs35477280	3:45932600	G	A	0.39	0.05	1.4E−17	0.48	0.06	6.3E−15	0.28	0.07	1.6E−05	FYCO1
rs4443214	3:46136372	T	C	0.25	0.04	9.0E−09	0.26	0.06	1.4E−05	0.26	0.06	4.4E−05	XCR1
rs115102354	3:46180545	A	G	0.41	0.07	1.6E−08	0.52	0.10	2.1E−07	0.32	0.10	2.0E−03	CCR3
rs10813976	9:33426577	A	G	0.18	0.03	2.7E−08	0.16	0.04	2.5E−04	0.19	0.05	3.5E−05	AQP3
rs1230082	17:45422978	C	G	0.16	0.03	2.1E−08	0.17	0.04	2.8E−05	−0.15	0.04	2.5E−04	ARHGAP27
rs77127536	19:35687796	G	A	−0.22	0.04	1.3E−08	−0.25	0.05	2.1E−06	−0.19	0.05	4.3E−04	UPK1A/ZTBT32
rs17860169	21:33240996	A	G	0.19	0.03	2.3E−11	0.27	0.04	1.4E−11	0.12	0.04	3.7E−03	IFNAR2

Note: Representative SNPs were selected using the clump function of PLINK 1.9 (clumping parameters r² = 0.5, Pval = 5 × 10⁻⁸ and Pval₂ = 0.05). EA, effect allele; NEA, non-effect allele; beta, effect coefficient; SE, standard error.