Table 3. Physical activity.

Physical activity
➢ Defined by day-to-day physical activities throughout life
➢ Recommended FVIII/FIX trough levels according to comprehensive patient profiles: 39
- < 1% for those:
o < 2 years of age with no bleeds
o With poor adherence associated with complex venous access
o With no bleeds despite low-frequency dosing prophylaxis
- 1–3% for those:
o Sedentary with no recurrent bleeds in same joint, moderate/mild arthropathy, and no pro-bleeding comorbidities
o With moderate hemophilia and spontaneous bleeding in spite of basal factor at 1–2%
- 3–5% for those:
o On mild physical activity
- 5–15% for those:
o On high-risk physical activity
Limitations and unmet needs
➢ Setting up individualized programs of physical activity is time consuming for the practitioner; interdisciplinary teams are sometimes unavailable
➢ No agreement among guides regarding suitability of high-intensity physical activity according to patient profile
➢ Risk of unrealistic feeling of safety associated with the use of EHL factors
➢ Lack of evidence regarding efficacy of nonfactor products to cover high-intensity physical activity

Abbreviations: FVIII, factor VIII; FIX, factor IX; EHL, extended half-life.