Table 4. Pharmacokinetics.

Pharmacokinetics
➢ Aimed to describe factor plasma concentration over time and the differences between individuals
➢ PK analysis procedures:
- Traditional multiple sampling analyses: limited by need for washout period and high number of blood collections after a single infusion
- Population PK models: no washout period, low number of collections, consider patient's covariates
➢ PopPK tools: NONMEM-7, 69 myPKFiT, 46 WAPPS-HEMO (McMaster Pop-PK), 47 Hemotik 50 (see Table 5 )
Limitations and unmet needs
➢ Lack of awareness of PopPK models to guide personalized prophylaxis leads to misconceptions:
- Too complex to be used in daily practice
- Benefit is not superior
- Saving factor/doses rarely occurs
- Poor adherence precludes from obtaining benefit
➢ Time required to achieve expertise and use on a regular basis not suitable for rushed physicians
➢ Overuse

Abbreviations: PopPK, population pharmacokinetics.