Table 5. Comparison between different modern approaches to PopPK calculation in hemophilia.
| PopPK tool | Expertise required | Type/Cost | Product | PK estimation | Restricted to approved doses | Mobile app | Medical device | Dose calculator | Integration |
|---|---|---|---|---|---|---|---|---|---|
| NonMem 69 | ++ + ++ | Desktop/$$$ | All | Immediate | No | No | No | No | No |
| MyPKFiT 46 | ++ | Web app/free | Advate, Rixubis, or Adynovate |
Immediate | Yes | Yes | Yes | Yes | No |
|
WAPPS-Hemo
47
(McMaster PopPK) |
++ | Web app/free | All | > 24 h | No | Yes | Only MyPopPK version | Yes | Yes: WBDR, Florio, Haemoassist |
| Hemotik 50 | ++ | Web app | Nuwiq | Immediate | No | No | No | Yes | No |
Abbreviations: PopPK, population pharmacokinetics; PK, pharmacokinetics; WBDR, World Bleeding Disorders Registry; $$$, payment required.