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. 2022 Jul 28;6(11):1272–1283. doi: 10.1038/s41551-022-00911-4

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, Targeting the mouse Pcsk9 exon 1 splice donor with SauriABE8e and SaKKH-ABE8e in mouse Neuro-2A cells. The target adenine is A₉ with respect to the Sauri protospacer, A₅ with respect to SaKKH protospacer. b, A comparison of SaCas9 guide RNA scaffolds^1,2 on editing activity at the mouse Pcsk9 exon 1 splice donor. The SaCas9 sgRNA scaffold is used with the homologous SauriCas9 protein since the native sgRNA for SauriCas9 is not known.