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. 2022 Jul 28;6(11):1272–1283. doi: 10.1038/s41551-022-00911-4

Extended Data Fig. 4. In vivo off-target mRNA editing.

Extended Data Fig. 4

RNA was extracted from mouse livers treated with single-AAV8 SaKKH-ABE8e and untreated mouse livers, reverse transcribed, and cDNA amplicons from Aars, Canx, Ctnnb, and Usp38 mRNA were analyzed by HTS. Dots represent individual adenines across the sequenced amplicon (n = 3 mice).