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. 2022 Nov 11;5:1224. doi: 10.1038/s42003-022-04200-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a AAV construct (AAV9.Iba1.miR-9.T.miR-129-2-3p.T) and schematic of the virus injection. AAV (dose: 1.0 × 10¹⁰ vg/mouse) was injected into the wild-type and SCA1-Tg mouse cerebellum at 24 weeks of age. Three weeks after the viral injection, cerebellar sections were analyzed by immunohistochemistry. b–d GFP immunofluorescent image of the wild-type (WT) mouse cerebellum. e–g GFP immunofluorescent image of a sagittal section of the SCA1-Tg (B05) mouse cerebellum. Square regions in b and e were enlarged to c, d and f, g, respectively. Scale bars; 500 μm (b, e) and 20 μm (c, d, f, g). GL granule cell layer, ML molecular layer.