Table 3.

Serum urate (SU) change over 3-month periods in year 1 and flare occurrence at the next visit

Months	Flare assessment time	Flare status	N	Mean SU change (SD)	p	Patients with SU change > 30 µmol/L (%)	p-value, flare vs. no flare	Patients with SU change > 60 µmol/L (%)	p-value, flare vs. no flare	Patients with SU change > 90 µmol/L (%)	p-value, flare vs. no flare
0–3	Month 4	Flare +	41	170 (89)	0.13	95.1	0.63	85.4	0.33	78.0	0.86
	Month 4	Flare −	129	153 (85)		93.0		90.7		76.7
3–6	Month 9	Flare +	30	19 (82)	0.42	36.7	0.71	30.0	0.66	16.7	0.56
	Month 9	Flare −	127	22 (71)		40.2		26.0		12.6
6–9	Month 12	Flare +	47	10 (87)	0.36	38.3	0.43	31.3	0.55	14.9	0.24
	Month 12	Flare −	116	6 (67)		31.9		17.2		8.6
9–12	Month 24	Flare +	41	− 1 (63)	0.15	14.6	0.043	7.3	0.25	7.3	0.67
	Month 24	Flare −	113	11 (63)		31.0		14.2		8.8