Table 2.
Phenotypic features of female and castrated male Ossabaw and Göttingen minipigs undergoing ischaemia/reperfusion without or with prior ischaemic preconditioning
| Ossabaw minipigs | Göttingen minipigs | |||||||
|---|---|---|---|---|---|---|---|---|
| Ischaemia/reperfusion | Ischaemic preconditioning + Ischaemia/reperfusion |
Ischaemia/reperfusion | Ischaemic preconditioning + Ischaemia/reperfusion |
|||||
| Female (n = 15) |
Castrated male (n = 16) | Female (n = 15) |
Castrated male (n = 16) | Female (n = 5) |
Castrated male (n = 4) | Female (n = 5) |
Castrated male (n = 4) | |
| Age [months] | 16 ± 3 | 16 ± 3 | 15 ± 2 | 15 ± 2 | 14 ± 1 | 15 ± 1 | 14 ± 1 | 14 ± 1 |
| Body weight [kg] | 49 ± 9 | 53 ± 9 | 52 ± 6 | 48 ± 6 | 44 ± 5 | 45 ± 5 | 47 ± 4 | 40 ± 13 |
| Left ventricular pressure [mmHg] | 89 ± 9 | 90 ± 9 | 87 ± 7 | 86 ± 7 | 84 ± 5 | 79 ± 10 | 83 ± 7 | 94 ± 16 |
| Erythrocytes [106/mm3] | 6.1 ± 1.0 | 6.0 ± 1.0 | 6.0 ± 0.8 | 5.8 ± 0.8 | 5.4 ± 0.7 | 5.3 ± 0.7 | 5.1 ± 0.1 | 5.5 ± 0.7 |
| Leukocytes [103/mm3] | 8.8 ± 1.6 | 8.1 ± 1.6 | 8.4 ± 1.6 | 9.0 ± 1.9 | 5.4 ± 0.9 | 4.9 ± 0.7 | 7.0 ± 2.2 | 6.0 ± 0.7 |
| Platelets [103/mm3] | 293 ± 47 | 267 ± 47 | 284 ± 61 | 267 ± 75 | 426 ± 117 | 502 ± 67 | 417 ± 90 | 453 ± 71 |
| Na+ [mmol/L] | 143 ± 9 | 142 ± 9 | 142 ± 2 | 141 ± 2 | 139 ± 2 | 139 ± 2 | 141 ± 4 | 142 ± 3 |
| K+ [mmol/L] | 3.7 ± 0.3 | 3.6 ± 0.3 | 3.7 ± 0.4 | 3.7 ± 0.4 | 3.6 ± 0.3 | 3.9 ± 0.5 | 3.6 ± 0.4 | 3.8 ± 0.5 |
| Glucose [mg/dL] | 97 ± 24 | 89 ± 24 | 94 ± 26 | 82 ± 26 | 85 ± 24 | 82 ± 17 | 102 ± 28 | 115 ± 38 |
| Cholesterol [mg/dL] | 73 ± 17 | 71 ± 17 | 72 ± 9 | 70 ± 14 | 85 ± 11 | 68 ± 16 | 89 ± 15 | 86 ± 16 |
| HDL [mg/dL] | 28 ± 6 | 28 ± 6 | 28 ± 7 | 27 ± 5 | 40 ± 7 | 33 ± 7 | 38 ± 10 | 42 ± 7 |
| LDL [mg/dL] | 32 ± 11 | 32 ± 11 | 30 ± 3 | 30 ± 8 | 29 ± 7 | 23 ± 8 | 37 ± 14 | 33 ± 11 |
| Triglycerides [mg/dL] | 42 ± 15 | 39 ± 15 | 45 ± 12 | 40 ± 14 | 51 ± 13 | 40 ± 5 | 54 ± 14 | 64 ± 27 |
| hs-CRP [mg/dL] | < 0.02 | < 0.02 | < 0.02 | < 0.02 | < 0.02 | < 0.02 | < 0.02 | < 0.02 |
| AST [U/L] | 46 ± 6 | 51 ± 6 | 45 ± 10 | 48 ± 13 | 23 ± 6 | 26 ± 3 | 24 ± 5 | 29 ± 7 |
| GPT [U/L] | 81 ± 23 | 78 ± 23 | 70 ± 17 | 71 ± 18 | 42 ± 9 | 57 ± 9 | 44 ± 8 | 56 ± 13 |
| Creatinine [mg/dL] | 1.08 ± 0.21 | 1.05 ± 0.21 | 1.07 ± 0.19 | 1.07 ± 0.27 | 0.62 ± 0.13 | 0.70 ± 0.29 | 0.67 ± 0.05 | 0.83 ± 0.07 |
Baseline variables and laboratory parameters of female and castrated male Ossabaw minipigs and female and castrated male Göttingen minipigs undergoing myocardial ischaemia/reperfusion without or with prior ischaemic preconditioning
AST aspartate aminotransferase; GPT glutamate pyruvate transaminase; HDL high-density lipoproteins; hs-CRP high sensitivity C-reactive protein; LDL low-density lipoproteins