Table 1.
Short term effect high salt (4% in chow) diet followed by Amoxicillin treatment on hepatological parameters in mice.
| Parameters | Groups | Significance (p-value) | |||||
|---|---|---|---|---|---|---|---|
| CD | CD + A | HSD | HSD + A | CD versus CD + A | CD versus HSD | HSD versus HSD + A | |
| Hb (g/dl) | 15.46 ± 1.1 | 14.83 ± 0.6 | 15.33 ± 0.5 | 14.43 ± 0.5 | NS | NS | NS |
| RBC (106 cells/ml) | 9.40 ± 0.3 | 9.1 ± 0.4 | 9.26 ± 0.4 | 8.91 ± 0.4 | NS | NS | NS |
| HCT (%) | 58.23 ± 3.8 | 55.23 ± 2.8 | 55.43 ± 2.4 | 53.0 ± 2.9 | NS | NS | NS |
| MCV (g) | 61.9 ± 1.8 | 60.76 ± 0.3 | 60.5 ± 0.1 | 59.53 ± 0.2 | NS | NS | NS |
| MCH (pg) | 16.36 ± 0.5 | 16.26 ± 0.1 | 16.5 ± 0.2 | 16.16 ± 0.4 | NS | NS | NS |
| MCHC(g/dl) | 26.5 ± 0.2 | 26.83 ± 0.2 | 27.3 ± 0.2 | 27.2 + 0.7 | NS | NS | NS |
| RDW (%) | 10.25 ± .0.34 | 9.72 ± 0.11 | 10.2 ± 0.52 | 10.7 ± 0.30 | NS | NS | NS |
| WBC (106 cells/ml) | 9.41 ± 1.1 | 10.52 ± 0.8 | 6.45 ± 0.8 | 7.35 ± 1.4 | NS | 0.0016 | NS |
| Lymphocytes (106 cells/ml) | 96.3 ± 0.7 | 93.6 ± 1.3 | 95.96 ± 0.5 | 93.8 ± 0.9 | NS | NS | NS |
| Monocytes (%) | 1.06 ± 0.1 | 2.4 ± 0.7 | 2.3 ± 1.9 | 2.56 ± 0.5 | NS | NS | NS |
| Granulocytes (%) | 0.26 ± 0.08 | 0.43 ± 0.08 | 0.18 ± 0.03 | 0.27 ± 0.03 | NS | NS | NS |
| Thrombocytes (103/microL) | 407.66 ± 76.2 | 400.3 ± 50.5 | 664 ± 25.2 | 356.66 ± 67.9 | NS | < 0.0001 | < 0.0001 |
Values are expressed as the means ± SD. Data were analyzed by one-way ANOVA, followed by Bonferroni test, n = 6, p ≤ 0.05, NS = Not significant, CD: Standard—chow diet for 3 weeks; CD + A: Standard—chow diet for 3 weeks and subjected Amoxicillin treatment in 3rd week; HSD: High-salt diet for 3 weeks; HSD + A: High-salt diet for 3 weeks and subjected to Amoxicillin treatment in 3rd week.