Table 7.

Short term effect of high-salt (4% in chow) diet followed by Amoxicillin treatment on the mean relative abundance of major bacterial groups at genus level in mice.

Genus	Relative abundance (%)				Significance (Adjusted p-value)
	CD	CD + A	HSD	HSD. + A	CD versus CD + A	CD versus HSD	HSD versus HSD + A
Enterococcus	0.00 ± 0.000	0.00 ± 0.000	0.00 ± 0.000	0.30 ± 0.054	NS	NS	< 0.0001
Lactobacillus	4.50 ± 0.207	0.10 ± 0.031	8.50 ± 0.278	0.30 ± 0.054	< 0.0001	< 0.0001	< 0.0001
Streptococcus	0.00 ± 0.000	0.00 ± 0.000	0.50 ± 0.070	0.20 ± 0.044	NS	< 0.0001	< 0.0001
Unc Clostridiales	39.00 ± 0.487	0.6 ± 0.077	15.50 ± 0.361	4.60 ± 0.209	< 0.0001	< 0.0001	< 0.0001
Unc Clostridiaceae	0.10 ± 0.031	0.00 ± 0.000	0.50 ± 0.070	0.00 ± 0.000	NS	< 0.0001	< 0.0001
Candidatus Arthromitus	5.70 ± 0.231	0.1 ± 0.031	0.10 ± 0.031	0.10 ± 0.031	< 0.0001	< 0.0001	NS
Clostridium	0.00 ± 0.000	0.00 ± 0.000	1.40 ± 0.117	0.00 ± 0.000	NS	< 0.0001	< 0.0001
Dehalobacterium	0.60 ± 0.077	0.00 ± 0.000	0.10 ± 0.031	0.00 ± 0.000	< 0.0001	< 0.0001	< 0.0001
Unc Lachnospiraceae	9.50 ± 0.293	0.30 ± 0.054	1.00 ± 0.099	0.50 ± 0.070	< 0.0001	< 0.0001	0.0008
Blautia	0.10 ± 0.031	0.00 ± 0.000	0.00 ± 0.000	0.30 ± 0.054	NS	0.0007	< 0.0001
Coprococcus	0.80 ± 0.089	0.00 ± 0.000	1.00 ± 0.099	0.10 ± 0.031	< 0.0001	0.0016	< 0.0001
[Ruminococcus]	1.10 ± 0.104	0.10 ± 0.031	9.60 ± 0.294	0.20 ± 0.044	< 0.0001	< 0.0001	< 0.0001
Unc Peptostreptococcaceae	0.00 ± 0.000	0.00 ± 0.000	0.10 ± 0.031	0.60 ± 0.077	NS	0.0077	< 0.0001
Unc Ruminococcaceae	12.10 ± 0.326	0.10 ± 0.031	2.10 ± 0.143	0.30 ± 0.054	< 0.0001	< 0.0001	< 0.0001
Oscillospira	1.80 ± 0.132	0.10 ± 0.031	0.30 ± 0.054	0.10 ± 0.031	< 0.0001	< 0.0001	0.0028
Ruminococcus	1.90 ± 0.136	0.00 ± 0.000	0.30 ± 0.054	0.10 ± 0.031	< 0.0001	< 0.0001	0.0034
Veillonella	0.00 ± 0.000	0.00 ± 0.000	0.10 ± 0.031	0.30 ± 0.054	NS	0.0007	< 0.0001
Unc Erysipelotrichaceae	0.20 ± 0.044	0.1 ± 0.031	1.90 ± 0.136	0.20 ± 0.044	0.0019	< 0.0001	< 0.0001
Allobaculum	0.00 ± 0.000	0.00 ± 0.000	3.10 ± 0.173	0.00 ± 0.000	NS	< 0.0001	< 0.0001
Neisseria	0.00 ± 0.000	0.00 ± 0.000	0.40 ± 0.063	0.40 ± 0.063	NS	< 0.0001	NS
Desulfovibrio	3.00 ± 0.170	0.20 ± 0.044	6.80 ± 0.251	0.30 ± 0.054	< 0.0001	< 0.0001	< 0.0001
Klebsiella	0.50 ± 0.070	37.5 ± 0.484	0.80 ± 0.089	50.30 ± 0.497	< 0.0001	NS	< 0.0001
Haemophilus	0.00 ± 0.000	0.00 ± 0.000	0.40 ± 0.063	0.40 ± .0.063	NS	< 0.0001	NS
Bacteroides	0.20 ± 0.044	26.7 ± 0.442	0.20 ± 0.044	3.60 ± 0.186	< 0.0001	NS	< 0.0001
Prevotella	0.00 ± 0.000	0.50 ± 0.070	0.10 ± 0.031	0.20 ± 0.044	< 0.0001	0.0002	0.0002
Unc S24-7	4.10 ± 0.198	4.90 ± 0.215	1.00 ± 0.999	0.80 ± 0.089	< 0.0001	< 0.0001	NS
Fluviicola	0.10 ± 0.031	0.20 ± 0.044	0.00 ± 0.000	0.20 ± 0.044	0.0019	0.0002	< 0.0001
Unc Acidimicrobiales	0.10 ± 0.031	0.10 ± 0.031	0.60 ± 0.077	0.70 ± 0.083	NS	< 0.0001	NS
Rothia	0.00 ± 0.000	0.00 ± 0.000	0.40 ± 0.063	0.50 ± 0.070	NS	< 0.0001	0.0184
Bifidobacterium	0.00 ± 0.000	0.00 ± 0.000	0.20 ± 0.044	0.00 ± 0.000	NS	< 0.0001	< 0.0001
Unc Coriobacteriaceae	0.10 ± 0.031	0.00 ± 0.000	1.60 ± 0.125	0.10 ± 0.031	< 0.0001	< 0.0001	< 0.0001
Adlercreutzia	1.30 ± 0.113	0.1 ± 0.031	3.40 ± 0.181	0.40 ± 0.063	< 0.0001	< 0.0001	< 0.0001
0319-7L14	0.00 ± 0.000	0.00 ± 0.000	0.10 ± 0.031	0.10 ± 0.031	NS	< 0.0001	NS
Akkermansia	0.00 ± 0.000	0.10 ± 0.031	6.40 ± 0.244	7.80 ± 0.268	< 0.0001	< 0.0001	< 0.0001
Unc F16	0.10 ± 0.031	0.10 ± 0.031	11.60 ± 0.320	0.10 ± 0.031	NS	< 0.0001	< 0.0001
Unc RF 39	0.00 ± 0.000	0.00 ± 0.000	0.50 ± 0.070	0.00 ± 0.000	NS	< 0.0001	< 0.0001

Values are expressed as the means ± SD. Data were analyzed by ANOVA, followed by Bonferroni test, n = 6, p ≤ 0.05, NS = Not significant, CD: Standard—chow diet for 3 weeks; CD + A.: Standard—chow diet for 3 weeks and underwent Amoxicillin treatment in 3rd week; HSD: High-salt diet for 3 weeks; HSD + A.: High-salt diet for 3 weeks and underwent Amoxicillin treatment in 3rd week.