Table 8.
Short term effect of high-salt (4% in chow) diet followed by Amoxicillin treatment on the mean relative abundance of major bacterial groups at the species level in mice.
| Species | Relative abundance (%) | Significance (Adjusted p-value) | |||||
|---|---|---|---|---|---|---|---|
| CD | CD + A | HSD | HSD + A | CD versus CD + A | CD versus HSD | HSD versus HSD + A | |
| Paenibacillus | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.2 ± 0.044 | 0.1 ± 0.039 | NS | < 0.0001 | 0.0004 |
| Granulicatella | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.1 ± 0.039 | 0.1 ± 0.039 | NS | 0.0002 | NS |
| Enterococcus casseliflavus | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.3 ± 0.054 | NS | NS | < 0.0001 |
| Lactobacillus reuteri | 0.2 ± 0.044 | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.0 ± 0.000 | < 0.0001 | < 0.0001 | NS |
| Blautia producta | 0.1 ± 0.039 | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.2 ± 0.044 | < 0.0001 | 0.0004 | < 0.0001 |
| [Ruminococcus] gnavus | 1.1 ± 0.104 | 0.1 ± 0.039 | 9.6 ± 0.294 | 0.2 ± 0.044 | < 0.0001 | < 0.0001 | < 0.0001 |
| Veillonella dispar | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.1 ± 0.039 | 0.3 ± 0.054 | NS | 0.0013 | < 0.0001 |
| Eubacterium dolichum | 0.1 ± 0.039 | 0.1 ± 0.039 | 0.2 ± 0.044 | 0.3 ± 0.054 | NS | 0.0057 | 0.0057 |
| Brevundimonas diminuta | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.1 ± 0.039 | 0.1 ± 0.039 | NS | 0.0002 | NS |
| Neisseria subflava | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.3 ± 0.054 | 0.3 ± 0.054 | NS | < 0.0001 | NS |
| Haemophilus parainfluenzae | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.3 ± 0.054 | 0.4 ± 0.063 | NS | < 0.0001 | 0.0068 |
| Bacteroides acidifaciens | 0.1 ± 0.039 | 18.1 ± 0.385 | 0.1 ± 0.039 | 1.0 ± 0.099 | < 0.0001 | NS | < 0.0001 |
| Bacteroides uniformis | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.0 ± 0.000 | 2.2 ± 0.146 | NS | NS | < 0.0001 |
| Prevotella melaninogenica | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.2 ± 0.044 | NS | NS | < 0.0001 |
| Candidatus Microthrix parvicella | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.1 ± 0.039 | NS | NS | < 0.0001 |
| Candidatus Aquiluna rubra | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.1 ± 0.039 | 0.0 ± 0.000 | NS | < 0.0001 | < 0.0001 |
| Rothia mucilaginosa | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.4 ± 0.063 | 0.5 ± 0.070 | NS | < 0.0001 | 0.0184 |
| Bifidobacterium pseudolongum | 0.0 ± 0.000 | 0.0 ± 0.000 | 0.2 ± 0.044 | 0.0 ± 0.000 | NS | < 0.0001 | < 0.0001 |
| Akkermansia muciniphila | 0.0 ± 0.000 | 0.0 ± 0.000 | 6.4 ± 0.244 | 7.8 ± 0.268 | NS | < 0.0001 | < 0.0001 |
Values are expressed as the means ± SD. Data were analyzed by one-way ANOVA, followed by Bonferroni test, n = 6, p ≤ 0.05, NS = Not significant, CD: Standard—chow diet for 3 weeks; CD + A: Standard—chow diet for 3 weeks and subjected to Amoxicillin treatment in 3rd week; HSD: High-salt diet for 3 weeks; HSD + A: High-salt diet for 3 weeks and subjected to Amoxicillin treatment in 3rd week.