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. 2022 Nov 11;13:6827. doi: 10.1038/s41467-022-34626-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Detailed browser views (top), Hi-C contact maps (mid) and differential chromatin interactions (bottom) of three gene loci – A DppA2/4, B Epbh1, and C Oct4. Visible changes in interactions involving the Dppa2/4 locus and Ephb1 locus are highlighted through each plot. Although Oct4 shows a dramatic change in gene expression, the region does not alter its radial position within the nucleus (FISH experiments), which is also consistent with the lack of change in compartmentalization reported by dcHiC. Source data are provided as a Source Data file.