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. 2022 Nov 11;5:1230. doi: 10.1038/s42003-022-04156-4

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Fig. 8 — a As chondrocytes progress from a proliferating state to a hypertrophic state in the growth plate, they undergo a metabolic switch from a state of high glycolysis to a state of high oxidative phosphorylation and pentose phosphate pathway activity. b IGF2 balances the metabolic switch, such that when it is removed, hypertrophic Igf2 null chondrocytes experience heightened oxidative phosphorylation compared to WT chondrocytes.