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. 2022 Nov 11;12:19291. doi: 10.1038/s41598-022-23685-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ranking of genetic markers by 2 methods (a) MErf and (b) MEgbm. These curves shows the relative importance of genetic variants in predicting worsening of disability over time. Each line on the plot is a genetic marker. The color of the lines matches the color of the genetic variants. From left to right, the importance of a genetic marker in predicting worsening events changes over time (clinical visits).