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. 2022 Nov 11;12:19294. doi: 10.1038/s41598-022-23841-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mean plasma concentrations of SET-M33 on day 1 (A) and (C) and day 28 (B) and (D) of 4 weeks of daily intravenous (infusion) administration to male (A) and (B) and female (C) and (D) dogs at 0.5, 1.5 and 4.0 mg/kg/day. Symbols (circle, triangle or square) indicate a group mean value. Bars represent standard deviations. The graphs were plotted using GraphPad Prism for Windows version 5.03, GraphPad Software, San Diego, California USA, www.graphpad.com.