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. 2022 Nov 11;12:19294. doi: 10.1038/s41598-022-23841-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mean maximum plasma concentrations (C_max) of SET-M33 and mean areas under the plasma concentration–time curves (AUC_0-24), on day 1 and day 28 of 4 weeks of daily intravenous (infusion) administration of SET-M33 to beagle dogs at 0.5, 1.5 and 4.0 mg/kg/day. AUC_0-24 area under the plasma concentration–time curve in 24-h dosing intervals, C_max maximum plasma concentrations. Columns and bars represent group mean values and standard deviations, respectively. The graphs were plotted using GraphPad Prism for Windows version 5.03, GraphPad Software, San Diego, California USA, www.graphpad.com. Statistical analysis is not applicable to these experiments.