Table 1.
Group mean values of significant changes obtained in haematology, clinical biochemistry and urinalysis tests (group mean values ± standard deviation) in male and female rats treated intravenously once daily for seven days with 0 (vehicle = 0.9% saline solution), 10 and 20 mg/kg/day of SET-M33 peptide.
| Sex | Dose (mg/kg/day) | Haematology | Clinical biochemistry | Urinalysis | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Retic (× 1012/L) | Retic (%) | Urea (mmol/L) | Creat (µmol/L) | Gluc (mmol/L) | Chol (mmol/L) | Trig (mmol/L) | Na (mmol/L) | K (mmol/L) | Cl (mmol/L) | Ca (mmol/L) | Phos (mmol/L) | Total prot (g/L) | Alb (g/L) | SG1 | Vol (mL) | ||
| Male | 0 | 0.112 ± 0.0088 | 1.46 ± 0.131 | 4.82 ± 0.537 | 24 ± 1.9 | 12.58 ± 1.155 | 2.49 ± 0.213 | 0.81 ± 0.16 | 134 ± 1.1 | 4.4 ± 0.26 | 93 ± 1.2 | 2.48 ± 2.48 | 2.51 ± 0.106 | 55 ± 1.2 | 30 ± 1.8 | 1.0299 ± 0.006 | 7 ± 1.8 |
| 10 | 0.037** ± 0.007 | 0.46** ± 0.1 | 5.46 ± 0.756 | 41** ± 2.9 | 8.73** ± 1.741 | 2.79 ± 0.29 | 0.73 ± 0.139 | 136** ± 1.3 | 4.0* ± 0.18 | 96** ± 1.3 | 2.38** ± 0.036 | 2.31** ± 0.098 | 57 ± 1.2 | 31 ± 1 | 1.0163** ± 0.0044 | 11 ± 4.5 | |
| 20 | 0.027** ± 0.007 | 0.33** ± 0.096 | 8.52** ± 1.286 | 62** ± 3.3 | 7.64** ± 0.650 | 3.46** ± 0.325 | 0.85 ± 0.183 | 136** ± 0.4 | 4.1* ± 0.29 | 96** ± 0.6 | 2.54* ± 0.033 | 2.26** ± 0.081 | 62** ± 1.3 | 34** ± 1.6 | 1.0197** ± 0.0043 | 13 ± 7.6 | |
| Female | 0 | 0.086 ± 0.0109 | 1.14 ± 0.179 | 4.77 ± 1.894 | 27 ± 2.4 | 8.31 ± 1.051 | 2.52 ± 0.448 | 0.57 ± 0.213 | 137 ± 1.2 | 3.8 ± 0.24 | 97 ± 1.5 | 2.44 ± 0.073 | 1.92 ± 0.138 | 57 ± 4 | 35 ± 1.9 | 1.0328 ± 0.0173 | 5 ± 3 |
| 10 | 0.065 ± 0.0266 | 0.85 ± 0.323 | 5.79 ± 0.971 | 46** ± 6 | 7.57 ± 0.884 | 2.99 ± 0.241 | 0.75 ± 0.127 | 136 ± 1.1 | 3.6 ± 0.21 | 97 ± 1.1 | 2.46 ± 0.079 | 1.96 ± 0.187 | 61 ± 2.8 | 34 ± 1.5 | 1.0154* ± 0.0079 | 18 ± 8.4 | |
| 20 | 0.043** ± 0.008 | 0.57** ± 0.143 | 7.63* ± 1.941 | 57** ± 9.7 | 7.15 ± 1.529 | 3.09 ± 0.574 | 0.93* ± 0.213 | 136 ± 0.5 | 3.6 ± 0.36 | 97 ± 2 | 2.5 ± 0.54 | 2.05 ± 0.26 | 60 ± 3 | 33 ± 0.9 | 1.0142* ± 0.0045 | 20* ± 14.8 | |
Retic reticulocyte count (absolute and relative), Creat creatinine, Gluc glucose, Chol total cholesterol, Trig triglycerides, Na sodium, K potassium, Cl chloride, Ca calcium, Phos inorganic phosphorus, Total Prot total protein, Alb albumin, SG1 specific gravity, Vol volume.
Significant differences between peptide vs. control groups are expressed at 5% (*p < 0.05) or 1% (**p < 0.01) level. For statistical analysis, Dunnett, Shirley or Williams tests were used.