Table 5.
Major differences of urea and creatinine in clinical biochemistry values (group mean values ± standard deviation) in beagle dogs treated with intravenous 30 min-short infusion of SET-M33 at 0 (vehicle = 0.9% saline solution), 4.0 and 8.0 mg/kg/day (7-day treatment period).
| Sex | Dose (mg/kg/day) | Urea (nmol/L) | Creatinine (µmol/L) | ||
|---|---|---|---|---|---|
| Pre-dose | End of treatment | Pre-dose | End of treatment | ||
| Male | 0 | 5.15 | 4.58 | 79 | 58 |
| 4.0 | 4.31 ± 0.849 | 4.92 ± 0.035 | 84 ± 18.4 | 77 ± 2.8 | |
| 8.0 | 4.26 ± 0.064 | 7.64 ± 0.191 | 66 ± 4.2 | 115 ± 25.5 | |
| Female | 0 | 4.57 | 5.2 | 58 | 58 |
| 4.0 | 3.76 ± 0.156 | 4.76 ± 0.021 | 69 ± 17.7 | 79 ± 2.8 | |
| 8.0 | 6.29 ± 2.15 | 7.94 ± 0.099 | 85 ± 23.3 | 103 ± 0 | |
Statistical analysis was not performed due to the small number of animals.