Table 7.
Pharmacokinetic parameters of SET-M33 on day 1 and day 28 of 4 weeks of daily intravenous (slow bolus) administration to male and female rats at 5, 9 and 15 mg/kg/day (group mean values).
| Time | Parameters | Units | 5 mg/kg/day | 9 mg/kg/day | 15 mg/kg/day | |||
|---|---|---|---|---|---|---|---|---|
| Male | Female | Male | Female | Male | Female | |||
| Day 1 | tmax | minutes | 5 | 5 | 5 | 5 | 5 | 5 |
| Cmax | ng/mL | 2227 | 2107 | 4563 | 3503 | 6043 | 5727 | |
| AUC0-t | ng ∙ h/mL | 692 | 663 | 1433 | 1152 | 2236 | 1944 | |
| Day 28 | tmax | minutes | 5 | 5 | 5 | 5 | 5 | 5 |
| Cmax | ng/mL | 3017 | 4103 | 5890 | 12,387 | 8170 | 13,567 | |
| AUC0-t | ng ∙ h/mL | 938 | 1218 | 1819 | 3558 | 2734 | 4111 | |
Cmax maximum plasma concentrations, tmax time at which Cmax occurred, AUC0-t area under the curve from zero to last quantifiable sampling time. Statistical analysis is not applicable to these experiments.