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. 2022 Nov 11;13:6835. doi: 10.1038/s41467-022-34462-8

Fig. 8. Biocompatibility evaluation of NIR-activatable ARNGs@TMZ/ICG.

Fig. 8

ac Cytotoxicity and in vivo biocompatibility assessment of ARNGs@TMZ/ICG. White blood cell (WBC) (a), red blood cell (RBC) (b) and hemoglobin (HGB) (c) levels in blood samples were assessed after a single dose tail vein injection. Data are presented as mean ± SD. df Blood chemistry examinations. Plasma alkaline phosphatase (ALP) (d), alanine aminotransferase (ALT) (e) and aspartate aminotransferase (AST) (f) levels were assessed after a single dose tail vein injection. Data are presented as mean ± SD. gl Expression of sentinel proinflammatory cytokines TNF-α, Il-1β and Il-6 in liver (gi) and kidney (jl) assessed on Day 2 and 14 after a single dose tail vein injection. Data are presented as mean ± SD (n = 4 independent samples, one-way ANOVA and Tukey multiple comparisons tests).