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. 2022 Nov 11;8:122. doi: 10.1038/s41523-022-00487-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Box plots representing level of inflammatory markers over time (a, c, e) and % change from pre-treatment to cycle 2 day 1 (b, d, f). There were no significant differences in changes from baseline to cycle 2 day 1 between responders and non-responders. Whisker endpoints represent range (minimum-maximum), box limits represent interquartile range (upper and lower quartiles), and center line represents the median. Points above the box-and-whiskers represent outliers. Horizontal dashed red line in panels b, d, f represent zero line for reference.