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. 2022 Sep 8;15(11):2685–2696. doi: 10.1111/cts.13394

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© 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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In vivo CYP2C19 activity and jejunal and hepatic protein expression in paired samples. Boxplot with individual points of (a) the 5‐OH‐omeprazole/omeprazole ratio (in vivo CYP2C19 activity), (b) jejunal CYP2C19 concentration, and (c) hepatic CYP2C19 concentration. The dots are colored according to genotype. CYP, cytochrome P450; T2DM, type 2 diabetes mellitus. Jejunal CYP2C19 concentration was only available in 34 patients subjected to Roux‐en‐Y‐gastric bypass (RYGB). Hepatic CYP2C19 concentration was only available in 56 patients subjected to RYGB or cholecystectomy.