TABLE 2.
Genotype distribution in the three study groups
| Genotype (likely phenotype) | T2DM‐obesity (n = 29) | Obesity (n = 53) | Controls (n = 17) |
|---|---|---|---|
| CYP2C19 genotype | |||
| *1/*1 (NM) | 12 (41) | 21 (40) | 7 (41) |
| *17/*17 or *1/*17 (UM/RM) | 8 (28) | 22 (41) | 5 (29) |
| *1/*2 or *2/*17 (IM) | 7 (24) | 8 (15) | 5 (29) |
| *2/*2 or *2/*4 (PM) | 2 (7) | 2 (4) | 0 (0) |
| CYP3A4 genotype | |||
| *1/*1 (NM) | 27 (93) | 50 (94) | 15 (88) |
| *1/*22 (IM) | 2 (7) | 3 (6) | 2 (12) |
| CYP3A5 genotype | |||
| *1/*3 (IM) | 2 (7) | 6 (11) | 2 (12) |
| *3/*3 (PM) | 27 (93) | 47 (89) | 15 (88) |
| CYP1A2 genotype | |||
| *1/*1 or *1/*1F (NM) | 14 (48) | 25 (47) | 10 (59) |
| *1F/*1F (hyperinducer) | 15 (52) | 28 (53) | 7 (41) |
| CYP2C9 genotype | |||
| *1/*1 or *1/*2 (NM) | 26 (90) | 49 (92) | 16 (94) |
| *1/*3 or *2/*2 (IM) | 3 (10) | 4 (8) | 0 (0) |
| *3/*3 (PM) | 0 (0) | 0 (0) | 1 (6) |
Note: Data are presented as absolute numbers (%).
Abbreviations: CYP, cytochrome P450; IM, intermediate metabolizer; NM, normal metabolizer; PM, poor metabolizer; RM, rapid metabolizer; UM, ultrarapid metabolizer.