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. 2022 Nov 11;13:6830. doi: 10.1038/s41467-022-34515-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Phenotypes analyzed within the Ghrhr^lit/lit, mTOR^KI/KI and IF cohorts are denoted in blue, green and red, respectively. The forest plots show, for all three PAAIs examined in the present paper, standardized coefficients, with 95% confidence intervals, corresponding to the age effects (a, d, g), intervention effects (b, e, h) and intervention × age interactions (c, f, i) derived from linear models applied to all continuously distributed phenotypes included in the present study. Note that we have not included phenotype labels on the y-axes to allow for a compact data presentation. Phenotypes were sorted based on the coefficient of the age effect. For a given intervention, this order is preserved across all panels from left to right (showing age effects, intervention effects and intervention × age interactions) to permit comparison of coefficients across any given phenotype. Sample sizes (number of mice per group) underlying these analyses are detailed, for each phenotype and all PAAIs, in Supplementary Data 8, 10 and 13.