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. 2022 Nov 11;13:6830. doi: 10.1038/s41467-022-34515-y

Fig. 7. MTOR eQTL effects on aging-associated phenotypes in humans.

Fig. 7

 a–f Phenotyping results in a human cohort that included participants of both genders with an age range from 30–95 years. a Change in phenotype associated with MTOR eQTL dosage in a large deep-phenotyped human cohort, with the horizontal whiskers indicating the 95% confidence intervals of the mean effect estimate; * denotes p < 0.05 for the linear association between MTOR eQTL dosage and phenotype The association between eQTL dosage and each phenotypic measure was assessed using multiple linear regression models adjusted for age, sex and population stratification using the first ten genetic principal components. Our analyses are based on unadjusted p-values. Change of body fat (b), percentage of body fat (c), body weight (d), plasma creatine concentration (e) and metabolic equivalent hours (f) associated with MTOR eQTL dosage in 30–49 years old (red line), 50–69 years old (green line) and 70–95 years old humans (blue line); the lines represent the best-fit least squares regression lines with surrounding 95% confidence intervals of the mean indicated in gray. The eQTL dosage was coded as GG = 0, CG = 1, and CC = 2 (GG is associated with lowest expression levels, CC with highest; see Supplementary Fig. 8b). Sample size was 997 human participants per age group. Created with BioRender.com.