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. 2022 Nov 11;12:19323. doi: 10.1038/s41598-022-24103-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Empagliflozin alleviates kidney damage after renal I/R injury in mice. (A) A schematic representation of the experimental design. (B, C) Serum levels of creatinine (CREA) (B) and blood urea (UREA) (C) in mice subjected to 45 min of renal ischemia followed by 24 h of reperfusion. n = 6 per group. Sham sham-operated, I/R ischemia/reperfusion, EMPA empagliflozin. (D) Kidney weight-to-tibia length (KW/TL) ratio of the mice treated with empagliflozin or vehicle post-IR. n = 6 per group. Data shown are the mean ± SD. Significant differences between groups were determined by one-way ANOVA (B–D).