Table 1. Patient characteristics.
| Characteristics | Patients receiving colistin sulfate |
|---|---|
| Male | 40 (80.0) |
| Weight (kg) | 70 (56.8–86.5) |
| T (℃) | 38.3±1.0 |
| MV | 42 (84.0) |
| CRRT | 14 (28.0) |
| Septic shock | 29 (48.0) |
| SOFA score | 10.9±4.3 |
| APACHE II score | 24.3±5.3 |
| CKD | 1 (2.0) |
| Prior hospitalization | 12 (5–17.3) |
| ICU stay (days) | 30 (19.3–47.3) |
| Total length of stay (days) | 37 (25–67.3) |
| 28-day mortality | 22 (44.0) |
| Bacteria eradication | 20 (40.0) |
| Favorable clinical response | 29 (58.0) |
| Laboratory parameters (before CS treatment) | |
| WBC (×109/L) | 11.56 (7.9–18.0) |
| N (×109/L) | 9.6 (6.7–16.5) |
| CRP (mg/L) | 113.2 (74.1–165.5) |
| PCT (ng/mL) | 2.21 (0.9–6.0) |
| PLT (×109/L) | 91 (60.1–188.3) |
| TBIL (μmol/L) | 27.25 (19.4–91.8) |
| Cr (μmol/L) | 91.4 (66.8–121.8) |
| Alb (g/L) | 31.05 (28.3–34.2) |
| Lac (mmol/L) | 26 (1.7–3.6) |
| Bacterial | N=70 |
| AB | 23 (32.9) |
| KP | 20 (28.5) |
| PA | 12 (17.1) |
| Fungus | 3 (4.3) |
| Other | 12 (17.0) |
| Infection sites | N=64 |
| POSI | 4 (6.3) |
| Pulmonary infection | 43 (67.2) |
| Intraperitoneal infection | 4 (6.3) |
| Incision infection | 2 (3.1) |
| Central venous catheter | 1 (1.6) |
| Other | 10 (15.6) |
| Duration of CS treatment days | 11 (7–16.3) |
| Nephrotoxicity | |
| Baseline | 22 (44.0) |
| After treatment | 12 (24.0) |
Data are shown as mean ± SD, median (IQR) or n (%). IQR, interquartile range; SD, standard deviation; T, temperature; MV, mechanical ventilation; CRRT, continuous renal replacement therapy; SOFA, Sequential Organ Failure Assessment; APACHE II, Acute Physiology and Chronic Health Evaluation II; CKD, chronic kidney disease; ICU, intensive care unit; CS, colistin sulfate; WBC, white blood cell; N, neutrophils; CRP, C-reaction protein; PCT, procalcitonin; PLT, platelet; TBIL, total bilirubin; Cr, creatinine; Alb, albumin; Lac, lactate; AB, Acinetobacter baumannii; KP, Klebsiella pneumoniae; PA, Pseudomonas aeruginosa; POSI, postoperative surgical infection.