Table 2. Characteristics associated with 28-day mortality among patients who received colistin sulfate.
| Characteristics | Survivors (n=28) | Non-survivors (n=22) | P value |
|---|---|---|---|
| Age (years) | 66 (47.5–84.3) | 79 (65.8–88) | 0.78 |
| Male | 22 (78.6) | 18 (81.8) | 1.0 |
| Weight (kg) | 60 (55.0–75.0) | 59 (54.3–70.0) | 0.445 |
| T (℃) | 38.4±0.81 | 37.9±1.1 | 0.098 |
| SOFA score | 10.0±4.3 | 12.0±4.1 | 0.119 |
| APACHE II score | 23.2±6 | 25.6±3.8 | 0.084 |
| MV | 23 (82.1) | 19 (86.4) | 0.988 |
| CRRT | 3 (10.7) | 11 (50.0) | 0.02 |
| Shock | 15 (53.6) | 14 (63.6) | 0.569 |
| Dose | 1.5 (1.5–1.5) | 1.5 (1.5–1.5) | 0.117 |
| ICU stay (days) | 42 (21.3–61.3) | 24 (16.5–31.5) | 0.007 |
| Total length of stay (days) | 57 (268–87.8) | 31.5 (18.8–41.8) | 0.007 |
| MV (days) | 25.5 (14.3–58.5) | 20 (11.5–30) | 0.17 |
| Duration of CS use (days) | 14.5 (9.3–19.8) | 10 (6–11.5) | 0.002 |
| Cumulative CS dose (million IU) | 20.71±8.36 | 13.9±5.4 | 0.001 |
| WBC (109/L) | 11.56 (7.0–17.9) | 12.11 (8.4–18.3) | 0.792 |
| N (109/L) | 8.75 (5.7–15.6) | 12.4 (7.0–22.5) | 0.348 |
| CRP (mg/L) | 89.6 (64.2–146.5) | 131.7 (87.4–200.2) | 0.107 |
| PCT (ng/mL) | 2.38 (0.8–7.0) | 2.21 (1.3–6.0) | 0.703 |
| PLT (109/L) | 120 (71–198) | 76 (36.5–162.5) | 0.113 |
| TBIL (μmol/L) | 32.05 (19.2–89.0) | 23.8 (19.4–111.6) | 0.113 |
| Cr (μmol/L) | 82.15 (61.9–129.9) | 97.8 (68.6–119.7) | 0.406 |
| Alb (g/L) | 30.55 (28.5–34) | 31.45 (27.9–35.0) | 0.907 |
| Lac (mmol/L) | 2.6 (1.6–3.53) | 2.75 (1.78–4.3) | 0.525 |
| Bacteria eradication | 18 (64.3) | 11 (50.0) | 0.31 |
| Baseline nephrotoxicity | 8 (28.6) | 14 (63.6) | 0.013 |
| Nephrotoxicity after therapy | 7 (25.0) | 13 (59.1) | 0.015 |
Data are shown as mean ± SD, median (IQR) or n (%). IQR, interquartile range; SD, standard deviation; T, temperature; SOFA, Sequential Organ Failure Assessment; APACHE II, Acute Physiology and Chronic Health Evaluation II; MV, mechanical ventilation; CRRT, continuous renal replacement therapy; ICU, intensive care unit; CS, colistin sulfate; WBC, white blood cell; N, neutrophils; CRP, C-reaction protein; PCT, procalcitonin; PLT, platelet; TBIL, total bilirubin; Cr, creatinine; Alb, albumin; Lac, lactate.