Table 2. Topological parameters of 19 hub targets for treating gastrointestinal hemorrhage with GFP.

Target	Description	UniProt	Degree	BC	CC
STAT3	Signal transducer and activator of transcription 3	P40763	52	0.115	0.545
SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	45	0.097	0.538
PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha	P27986	44	0.067	0.523
TP53	Cellular tumor antigen p53	P04637	43	0.109	0.512
JUN	Transcription factor AP-1	P05412	41	0.070	0.517
MAPK1	Mitogen-activated protein kinase 1	P28482	39	0.064	0.510
RELA	Transcription factor p65	Q04206	39	0.057	0.512
AKT1	RAC-alpha serine/threonine-protein kinase	P31749	34	0.057	0.493
TNF	Tumor necrosis factor	P01375	32	0.027	0.472
IL6	Interleukin-6	P05231	30	0.027	0.473
MAPK14	Mitogen-activated protein kinase 14	Q16539	28	0.019	0.489
ESR1	Estrogen receptor	P03372	25	0.013	0.469
STAT1	Signal transducer and activator of transcription 1-alpha/beta	P42224	23	0.014	0.463
VEGFA	Vascular endothelial growth factor A	P15692	23	0.011	0.459
EGFR	Epidermal growth factor receptor	P00533	22	0.014	0.464
CDKN1A	Cyclin-dependent kinase inhibitor 1	P38936	22	0.011	0.462
CREB1	Cyclic AMP-responsive element-binding protein 1	P16220	19	0.007	0.459
HIF1A	Hypoxia-inducible factor 1-alpha	Q16665	19	0.005	0.457
TGFB1	Transforming growth factor beta-1 proprotein	P01137	15	0.010	0.449

GFP, Gardeniae fructus Praeparatus; BC, betweenness centrality; CC, closeness centrality.