Table 1. Detailed information for top 10 pathway.

Pathway	Hub genes in pathway	Count	Adjp
IL-17 signaling pathway	MAPK14, RELA, JUN, FOS, MAPK1, IL6, NFKBIA	24	2.89E-22
TNF signaling pathway	MAPK14, RELA, JUN, AKT1, FOS, MAPK1, IL6, NFKBIA	24	1.6E-20
Th17 cell differentiation	MAPK14, RELA, JUN, FOS, MAPK1, IL6, NFKBIA, IL2	19	5.93E-15
Toll-like receptor signaling pathway	MAPK14, RELA, JUN, AKT1, MAPK1, IL6, NFKBIA	18	4.51E-14
C-type lectin receptor signaling pathway	MAPK14, RELA, JUN, AKT1, MAPK1, IL6, NFKBIA, L2	18	4.51E-14
PI3K-Akt signaling pathway	RELA, AKT1, MAPK1, IL6, IL2	29	7.58E-14
HIF-1 signaling pathway	RELA, AKT1, MAPK1, IL6	18	9.16E-14
T cell receptor signaling pathway	MAPK14, RELA, JUN, AKT1, FOS, MAPK1, NFKBIA	17	5.73E-13
Apoptosis	RELA, JUN, AKT1, FOS, MAPK1, NFKBIA	19	3.54E-13
MAPK signaling pathway	MAPK14, RELA, JUN, AKT1, FOS, MAPK1, MYC	25	2.58E-12

Adjp, adjust P value. IL-17, interleukin 17; TNF, tumor necrosis factor; HIF, Hypoxia-Inducible Factor; MAPK, mitogen-activated protein kinase.