Table 2. Molecular docking for hub genes and compound of HMM.

Number	Hub genes	Compound	Docking affinity (kcal/mol)
1	AKT1	Kaempferol	−9.6
2	AKT1	Quercetin	−9.4
3	ESR1	3,9-di-O-methylnissolin	−6.9
4	ESR1	7-O-methylisomucronulatol	−6.8
5	ESR1	Calycosin	−7.8
6	ESR1	Formononetin	−8.4
7	ESR1	Isorhamnetin	−8.0
8	FOS	Quercetin	−10.4
9	IL2	Quercetin	−7.9
10	IL6	Quercetin	−7.8
11	JUN	Formononetin	−8.4
12	JUN	Kaempferol	−9.2
13	JUN	Quercetin	−8.8
14	MAPK1	Quercetin	−8.4
15	MAPK14	7-O-methylisomucronulatol	−7.0
16	MAPK14	Calycosin	−8.2
17	MAPK14	Formononetin	−7.8
18	MAPK14	Isorhamnetin	−8.5
19	MYC	Quercetin	−7.6
20	NFKBIA	Quercetin	−7.7
21	RELA	Isorhamnetin	−9.2
22	RELA	Kaempferol	−9.5
23	RELA	Quercetin	−9.2

HMM, Hedysarum multijugum Maxim.