Box.
Previous studies on the dose-response association between late-life physical activity and dementia risk.
| Reference | Country | No. of participants | Age at baseline, mean±sd | Follow -up years | Incident dementia, | Exposure | HR (95% CI) | P for trend |
|---|---|---|---|---|---|---|---|---|
| Boongird P, et al.6 | Thailand | 206073 | 62.5±10.0 | 6 | 480 (0.2%) | Frequency of physical activity | No physical activity: 1 1–2 days/week: 0.864 (0.661–1.129) 3–5 days/week: 0.629 (0.504–0.785) >5 days/week: 0.413 (0.257–0.663) | NI |
| Wang HX, et al.7 | Sweden | 776 | 81.1±4.9 | 6 | 124 (15.9%) | Frequency of physical activity | No physical activity: 1† less than daily: 0.97 (0.42–2.22) daily: 0.41 (0.13–1.31) | NI |
| Neergaard JS, et al.8 | Netherland | 5512 | 70.1±6.4 | 11.9 | 592 (10.7%) | Frequency of physical activity | no physical activity: 1 1 time/ week: 0.77 (0.61–0.96) 2 times/week: 0.80 (0.61–1.04) ≥3 times/week: 0.79 (0.64–0.97) | NI |
| Liu Y, et al.9 | Japan | 51477 | 71.3±7.5 | 7 | 13816 (26.8%) | Frequency of physical activity | ≤1 time/week:1 ≥2 times/week but not every day: 0.79 (0.75‐0.84) every day: 0.94 (0.89‐0.98） | NI |
| Llamas-Velasco S, et al.10 | Spain | 3100 | 72.8 ± 6.1 | 3 | 134 (4.3%) | Duration of physical activity. Number of hours was weighted. Weighting facotrs were: 1.0 for sedentary, 1.2 for slight, 1.4 for moderate, and 1.8 for heavy activity. | ≤15.6 hours: 1 15.6<hours≤17.6 hours: 0.53 (0.34–0.82) 17.6<hours≤19.4 hours: 0.45 (0.27–0.76) >19.4 hours: 0.29 (0.16–0.52) | NS |
| Tan ZS, et al.11 | USA | 3174 | 70±7 | 7.5 | 236 (7.4%) | Duration of physical activity. Number of hours was weighted. Weighting facotrs were: 1.0 for basal, 1.1 for sedentary, 1.5 for slight, 2.4 for moderate, and 5.0 for heavy activity. | 1st quintile: 1 2nd quintile: 0.44 (0.27–0.73) 3rd quintile: 0.80 (0.52–1.22) 4th quintile: 0.63 (0.40–1.00) 5th quintile: 0.95 (0.63–1.41) | NI |
| Taaffe DR, et al.12 | Hawaii | 2263 | 71–93 (range) | 6.1 | 173 (7.6%) | Duration of physical activity. Number of hours was weighted. Weighting facotrs were: 1.0 for basal, 1.1 for sedentary, 1.5 for slight, 2.4 for moderate, and 5.0 for heavy activity. | ≤28.7 hours:1 28.8–32.4 hours: 0.57 (0.32–0.99) ≥ 32.5 hours: 0.50 (0.28–0.89) | NI |
| Feter N, et al.13 | England | 9275 | 63.8±10.8 | 15 | 631 (6.8%) | A composite score was genarated by summing answers to the frequency question and the intensity question. | Inactive: 1 Low: 0.40 (0.32–0.49) Moderate/high: 0.22 (0.17–0.30) | NI |
| Laurin D, et al.14 | Canada | 4615 | ≥65 (range) | 5 | 80 (1.7%)* | A composite score was genarated by summing answers to the frequency question and the intensity question. | No physical activity: 1.0 Low: 0.67 (0.39–1.14) Moderate: 0.67 (0.46–0.98) High: 0.50 (0.28–0.90） | 0.02 |
| Ogino E, et al.15 | USA | 1345 | 75.1±6.30 | 4.1 | 106 (7.9%)* | Amount of physical activity (unit: MET-minute/2 weeks) | 0 MET-minutes/2 weeks:1.00 0<MET-minutes/2 weeks<1260: 0.71 (0.44–1.15) ≥1260 MET-minutes/2 weeks: 0.42 (0.21–0.86) | 0.014 |
| Podewils LJ, et al.16 | USA | 3375 | 74.8±4.9 | 5.4 | 480 (14.2%) | Amount of physical activity (unit: kcal/week) | <248 kcal/week: 1† 248–742 kcal/week: 1.22 (0.93–1.60) 743–1,657 kcal/week: 0.94 (0.69–1.28) >1,657 kcal/week: 0.85 (0.61–1.19) | 0.11 |
sd=standard deviation. HR=hazard ration. CI=confidence interval. NI=no information. NS=not significant.
*:
incident Alzheimer’s disease
†:
relative risk