TABLE 3.
Cox regression analysis of time to antibodies to infliximab (ATI) development
HR | 95% CI | P value | |
---|---|---|---|
Age <10 years | 1.86 | 0.99–3.49 | 0.05 |
Starting dose <7.5 mg/kg | 2.09 | 0.98–4.45 | 0.05 |
Baseline Neutrophil CD64 activity ratio >6 | 2.55 | 1.14–5.70 | 0.02 |
Week 0–14 exposure (AUC) goal, 79 348 μg h/mL | 0.48 | 0.27–0.84 | 0.009 |
HLA DQA*105 | 0.75 | 0.38–1.50 | 0.43 |
Abbreviations: AUC, area under concentration curve; CI, confidence interval; HR, hazard ratio.