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. Author manuscript; available in PMC: 2023 Jun 20.
Published in final edited form as: Curr Biol. 2022 Jun 20;32(12):R684–R696. doi: 10.1016/j.cub.2022.04.071

Figure 5. Lipid mobilization by three types of autophagy.

Figure 5.

(A) Fatty acids are produced by macrolipophagy (lipophagy) of LDs. It is unclear whether a receptor protein is required in macrolipophagy. (B) Chaperone-mediated autophagy degrades LD coating proteins PLIN2 and PLIN3, and increases the accessibility of the “naked” LDs to both cytosolic lipolysis and lipophagy. (C) Micro-lipophagy mediates the direct engulfment of LDs by the vacuole/lysosome at the liquid-ordered domain. ESCRT proteins, Atg39 and a number of autophagy proteins are involved in micro-lipophagy.