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. 2022 Nov 12;20:525. doi: 10.1186/s12967-022-03741-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Celastrol inhibited the viability, migration, and invasion of NSCLC Cells. A Chemical structure of celastrol. B IC₅₀ values of celastrol in NSCLC cells. Three NSCLC cell lines were placed in a 96-well plate with various concentrations of celastrol (0–100 μmol) After 48 h, treatment with celastrol, MTT assay was employed to determine the proliferation ability of cells. GraphPad Prism 7.0 software was used to acquire proliferation curves. C Representative images of colony formation assay. After incubation with the indicated dose of celastrol for 12 h, colonies of four cell lines were recorded after about 7 days. D PC-9 cells were treated with celastrol (0, 1, 2, and 4 μM) and allowed to migrate into the scratched area. E Celastrol induced loss of invasion potential in NSCLC cells. Triple assays were repeated. (*P < 0.05, **P < 0.01, ***P < 0.001)