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. 2022 Nov 12;20:525. doi: 10.1186/s12967-022-03741-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The therapeutic action of celastrol in vivo. A Tumor volumes. B Representative figures of the tumor tissue in the celastrol-administered and control groups (n = 7). C Measurement of tumor weights. D Body weight of mice. E Hematoxylin and eosin staining of hearts, livers, lungs, and kidneys from nude mice at 200× magnification. F The expression of P-STAT3 and P-EIF2α was detected by IHC in tumor tissues. G Representative blots indicating the expressions of P-STAT3, ATF4, P-eIF2α BAX, BCL-2, STAT3, eIF2α, and GAPDH in tumor tissues. The images shown are representative of three separate experiments (**P < 0.01, ***P < 0.001, ****P < 0.0001)