TABLE 1.
Colonization of human gastric xenografts by H. pylori LB1 and H. pylori ATCC 49503
| H. pylori strain used in inoculation | Time (wk) after inoculation | No. of grafts positive/total no. of grafts studied
|
|||
|---|---|---|---|---|---|
| Mucus
|
Antral mucosa
|
||||
| Rapid urease test | Culture | Immuno-histochemistry | Culture | ||
| LB1a | 2 | 2/2 | 2/2 | 2/2 | 2/2 |
| 4 | 2/2 | 2/2 | 2/2 | 2/2 | |
| 8 | 1/2 | 1/2 | 2/2 | 2/2 | |
| 12 | 1/2 | 1/2 | 2/2 | 2/2 | |
| LB1b | 2 | 10/10 | 9/10 | 8/10 | 10/10 |
| 4 | 8/10 | 8/10 | 8/10 | 10/10 | |
| 8 | 6/10 | 6/10 | 9/10 | 10/10 | |
| 12 | 8/10 | 8/10 | 10/10 | 10/10 | |
| ATCC 49503c | 2 | 1/5 | 1/5 | 1/5 | 1/5 |
| 4 | 0/5 | 0/5 | 0/5 | 0/5 | |
| 8 | 0/5 | 0/5 | 0/5 | 0/5 | |
| 12 | 0/5 | 0/5 | 0/5 | 0/5 | |
| ATCC 49503d | 2 | 1/5 | 1/5 | 1/5 | 1/5 |
| 4 | 0/5 | 0/5 | 0/5 | 0/5 | |
| 8 | 0/5 | 0/5 | 0/5 | 0/5 | |
| 12 | 0/5 | 0/5 | 0/5 | 0/5 | |
a
Grafts were inoculated with H. pylori LB1 freshly isolated from humans (two in vitro passages).
b
Grafts were inoculated with H. pylori LB1 after isolation from initially inoculated grafts (four in vitro passages).
c
Grafts were inoculated with H. pylori ATCC 49503 before in vivo passage in graft.
d
Grafts were inoculated with H. pylori ATCC 49503 after isolation from initially inoculated graft (four in vitro passages).