Table 2.

Target volume outcomes

Study name	Citations	Functional imaging agent	Intervention aim							Treatment
			Improve standard RTtarget delineation	Facilitate doseescalation	Facilitate organ at risk sparing	Map recurrence & RT treated volumes	Map functional volumes& RT planning volumes	Map treated functionalvolumes & survival	Map radiomic features& RT volumes	Standard treatment	Standard targetvolumes changed	Dose escalation
Niyazi	[32, 33]	F18-FET PET					$✓$			$✓$
Piroth	[34–37]	F18-FET PET		$✓$		$✓$		$✓$			$✓$	$✓$
Munck Af Rosenschold	[40, 41]	F18-FET PET	$✓$				$✓$	$✓$			$✓$
Lundemann	[42–44]	F18-FET PET	$✓$			$✓$	$✓$		$✓$		$✓$
Poulsen	[45, 46]	F18-FET PET	$✓$					$✓$			$✓$
Harat	[47]	F18-FET PET				$✓$	$✓$			$✓$
Hayes	[48]	F18-FET PET	$✓$			$✓$	$✓$				$✓$
Fleischmann	[49]	F18-FET PET				$✓$	$✓$			$✓$
Hirata	[54, 55]	C11-MET & F18-FDG PET				$✓$	$✓$	$✓$		$✓$
Christensen	[57]	C11-AMT PET				$✓$	$✓$			$✓$
Kosztyla	[58]	F18-FDOPA PET				$✓$	$✓$			$✓$
Windisch	[62, 63]	FAP PET					$✓$			$✓$
Munshi	[64]	DCE MRI					$✓$			$✓$
Wahl	[65]	DW & DCE MRI				$✓$	$✓$	$✓$		$✓$
Berberat	[69]	DTI MRI				$✓$	$✓$			$✓$
Altabella	[72]	DTI MRI			$✓$					$✓$
Peeken	[73]	DTI MRI				$✓$	$✓$		$✓$	$✓$
Morin	[74]	DW MRI	$✓$			$✓$	$✓$			$✓$
Laprie	[77–80]	MRSI		$✓$								$✓$
Gurbani	[84]	MRSI				$✓$	$✓$					$✓$

Study name	RT target volume details
	GTV-S (cm${}^3$)	GTV-F (cm${}^3$)	GTV-S+F (cm${}^3$)	CTV-S (cm${}^3$)	CTV-F (cm${}^3$)	CTV-S+F (cm${}^3$)	PTV-S (cm${}^3$)	PTV-F (cm${}^3$)	PTV-S+F (cm${}^3$)	CTV Target change (%)	PTV Target change (%)	Boost Volume (cm${}^3$)
Niyazi	x 34.1	x 43.9	x 48	x 224.5	x 240.3	x 286.8	x 343.5	x 356.5	x 416.5	x +27.7	x +21.1
Piroth	$\overline{x}$ 5.2	$\overline{x}$ 14.3					$\overline{x}$ 219.5					$\overline{x}$ 14.3
Munck Af Rosenschold	x 37	x 19.8	x 38.2	$\overline{x}$ 275	$\overline{x}$ 290	$\overline{x}$ 300				$\overline{x}$ +9.1
Lundemann	x 33.8	x 21.4	x 41.6
Poulsen		x 21.8
Harat		x 30.4
Hayes				x 83.6		x 94.7				x +13.3
Fleischmann	x 14.0	x 19.8	x 30.8				x 297.8		x 271.3		x $-$8.9
Hirata	x 9.9	x 60.4	x 60.4
Christensen	$\overline{x}$ 50.2	$\overline{x}$ 48.9	$\overline{x}$ 67.6
Kosztyla	$\overline{x}$ 30.8	$\overline{x}$ 58.6	$\overline{x}$ 63.5	$\overline{x}$ 249	$\overline{x}$ 306	$\overline{x}$ 312	$\overline{x}$ 369	$\overline{x}$ 437	$\overline{x}$ 445	$\overline{x}$ +25.3	$\overline{x}$ +20.6
Windisch	x 33.8	x 23.8 - 49.6	x 60.8				x 271
Munshi	x 40.8	x 17.2	x 46.3	x 200.1		x 221.0	x 258		x 286	x +10.4	x +10.8
Wahl	$\overline{x}$ 37.8	$\overline{x}$ 21.4
Berberat										$-$50	$-$15
Altabella							$\overline{x}$ 543
Peeken	x 23.3	x 5.9		x 207.2${}^{\alpha }$ - 276.8${}^{\beta }$		x 240.9				x -13.0 - +16.3
Morin										x -26.7
Laprie									x 307.8			x 97.63
Gurbani		50.6										$\le$ 65

S Standard contouring, F Functional imaging used, S+F= combined, x = Median, $\overline{x}$ = Mean, $\alpha$ = EORTC guidelines, $\beta$ = RTOG guidelines