Table 5.

Survival analyses when functional imaging incorporated in radiation therapy planning

Study name	Citation	N (patients)	Intervention	Median OS (months)	Median PFS (months)	12 Mths OS %	12 Mths PFS %
Piroth	[34–37]	22	F18-FET & 72 Gy/30 fractions boost	14.8 (95% CI 12.7–16.0)	7.8 (95% CI 5.1–10.5)	63.6	25.4
Laouiti	[38]	12	F18-FET & 72 Gy/30 fractions boost			38.4	28.6
Miwa	[39]	51	F18-FET & 68 Gy/8 fractions boost	20	13	71.2	52.6
Munck Af Rosenschold	[40, 41]	190	F18-FET	15 (range 2.04–48.0)	6 (range 2.04–48.0)
Lundemann	[42–44]	15	F18-FET	20.74 (range 9.53–25.12)	11.7 (range 4.06–17.91)
Poulsen	[45, 46]	146	F18-FET	16.5	6.5
Vigil	[52, 53]	50	C11-MET & boost	20	6.7
Brinkmann	[59, 61, 61]	75	F18-FDOPA & 76 Gy/30 fractions boost	16	8.7
Kim	[66, 68, 86]	25	DW & DCE & 75 Gy/30 fractions boost	20 (95% CI 14-NA )		90 (95% CI 0.8–1.0)
Zhang	[71]	100	DTT	17.6 (range 6–42)		76	66
Stupp et al.	[9]	573	Historical control	14.6 (95% CI 13.2–16.8)	6.9 (95% CI 5.8–8.2)	61.1	26.9
Analysis all		686	Functional imaging	16.88	7.44	70.86	55.05
Analysis boost		235	Functional imaging & boost	18.52	9.31	73.05	42.17

Bold indicate that it is different type of data than the data directly above

N Number of, OS Overall survival, PFS Progression free survival, Mths Months, NA Non applicable, Analyses formula = (n1(f1) + n2(f2 )+... n5(f5))/n total