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Nicotine-induced enhancement of total (5 day) METH intake in male adolescent and female adult rats. Mean total METH intake (mg/kg) ± SEM in female (A) and male (B) Sprague-Dawley rats. ***p < .001 Nic versus Sal intake; +p < .05 adult versus adolescent nicotine-exposed animals; n = 8–11/group. Open and closed circles represent individual female animals, open and closed squares represent individual male animals. METH = methamphetamine; Nic = nicotine; Sal = saline.
